Buy O-304 (ATX-304) 100mg x60 Capsules
Pan-AMPK activator for metabolic syndrome, exercise mimicry, and body composition
Verified O-304 (ATX-304) 100mg x60 Capsules — O-304 (ATX-304) is a first-in-class pan-AMPK activator in clinical trials that produces exercise-like metabolic effects — improving insulin sensitivity, reducing fat, and enhancing vascular function.
- First-in-class pan-AMPK activator in clinical trials
- Reduces fasting glucose and improves insulin sensitivity
- Promotes fat oxidation and reduces visceral adiposity
- Improves vascular function via eNOS activation
- Oral capsule format for convenient daily dosing
COA verified · US domestic shipping
O-304 (ATX-304): The Pan-AMPK Activator in Clinical Trials for Metabolic Syndrome and Cardiovascular Disease
Pan-AMPK Activation
O-304 activates all AMPK complexes simultaneously — delivering more complete exercise-mimetic metabolic signaling than any previous AMPK-targeting compound.
Clinical Trial Validation
Phase I/IIa data confirms reductions in fasting glucose, improved insulin sensitivity, and visceral fat loss in T2D patients — regulatory-grade evidence for its metabolic efficacy.
Vascular Function Improvement
Beyond metabolic effects, O-304 improves microvascular blood flow via eNOS activation — addressing the vascular component of metabolic syndrome that pure metabolic agents miss.
ADaM Site Binding
O-304 uses AMPK's allosteric activation site (ADaM) — a mechanism that both activates the enzyme and protects its activation from being reversed, sustaining the metabolic signal.
The Science Behind O-304 (ATX-304) 100mg x60 Capsules
▸The Clinical-Stage Pan-AMPK Activator
O-304 (ATX-304) is a small molecule pan-AMPK activator developed by Betagenon AB, currently in Phase IIb trials for type 2 diabetes and cardiovascular disease. As a "pan" activator, it activates all AMPK heterotrimeric complexes — not just the α2β1γ1 form activated by existing agents — producing a more complete exercise-mimetic metabolic response than any previous AMPK activator.
▸Mechanism: Comprehensive AMPK Activation
O-304 binds to the ADaM (allosteric drug and metabolite) site on AMPK, activating the enzyme allosterically and protecting it from dephosphorylation simultaneously. Pan-AMPK activation coordinates glucose uptake, fatty acid oxidation, mitochondrial biogenesis, and vascular relaxation (via eNOS activation) — producing a metabolic state that closely mimics sustained aerobic exercise across multiple tissues.
▸Clinical Evidence
Phase I/IIa trials demonstrated that O-304 significantly reduced fasting glucose, improved insulin sensitivity, reduced visceral fat, and improved peripheral blood flow in type 2 diabetic patients. The concurrent vascular effects — including improved microvascular blood flow — make O-304 particularly relevant for metabolic syndrome, where vascular dysfunction accompanies insulin resistance and obesity.
Complete O-304 (ATX-304) 100mg x60 Capsules Benefits
- First-in-class pan-AMPK activator in clinical trials
- Reduces fasting glucose and improves insulin sensitivity
- Promotes fat oxidation and reduces visceral adiposity
- Improves vascular function via eNOS activation
- Oral capsule format for convenient daily dosing
- Exercise-mimetic effects without physical exertion requirement
- 60-capsule supply for complete metabolic improvement cycle
O-304 (ATX-304) 100mg x60 Capsules Dosing Protocol
Dosing:
• Metabolic improvement: 100mg orally daily with food (per clinical protocol)
• Exercise mimicry: 100–200mg daily for 8–12 weeks
• Cycle: 12-week cycles aligned with clinical trial protocols
Capsule format: Take with food; clinical trials used once-daily oral dosing
All information on this site is for educational purposes only. Always consult with a qualified healthcare provider before use. COA documentation is available for all products.
O-304 (ATX-304) 100mg x60 Capsules
COA verified · Third-party tested · US domestic shipping
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