Buy LL-37 5mg

▸The Body's Own Defense Molecule

LL-37 is a 37-amino-acid peptide that is the sole human cathelicidin, part of the innate immune system's first-line defense against pathogens. Named for its leucine-leucine (LL) N-terminus and 37-amino-acid length, it is naturally produced by neutrophils, macrophages, and epithelial cells. Beyond its antimicrobial activity, LL-37 has emerged as a potent regulator of immune responses, wound healing, and angiogenesis.

▸Multi-Modal Mechanism

LL-37 disrupts bacterial membranes through electrostatic interactions, killing gram-positive and gram-negative bacteria, fungi, and some viruses. Simultaneously, it acts as an immune modulator — activating immune cells, promoting macrophage recruitment, and inducing anti-inflammatory signaling in chronic wound environments. It also stimulates keratinocyte and endothelial cell migration, accelerating wound closure and re-epithelialization.

▸Research and Clinical Potential

LL-37 deficiency has been linked to chronic non-healing wounds, recurrent skin infections, and inflammatory conditions. Research is investigating its therapeutic applications in chronic wound management, antibiotic-resistant infections, lung conditions, and even cancer immunotherapy due to its ability to activate dendritic cells.