Buy ARA-290 4mg

ARA-290 is an 11-amino-acid peptide derived from the helix-B surface of erythropoietin (EPO) — engineered to retain EPO's tissue-protective and anti-inflammatory effects while eliminating red blood cell stimulation. This makes ARA-290 safe for repeated use without the hematopoietic risks associated with EPO itself.

▸Mechanism: Innate Repair Receptor

ARA-290 acts through the Innate Repair Receptor (IRR), a heterodimer of the EPO receptor and the beta common receptor (CD131). This receptor is expressed on damaged and inflamed tissues — ARA-290 specifically targets tissue under stress and activates repair pathways only where they're needed.

▸Clinical Evidence for Neuropathy

Phase II clinical trials in sarcoidosis patients with small fiber neuropathy demonstrated significant improvements in pain scores, nerve fiber density, and quality of life measures. The peptide promoted small fiber nerve regrowth in patients with established neuropathic damage — a finding with significant implications for diabetic peripheral neuropathy, chemotherapy-induced neuropathy, and other causes of small fiber loss.

▸Anti-Inflammatory Action

ARA-290 reduces production of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) at injury sites while promoting M2 macrophage polarization — shifting the immune response from destructive inflammation toward repair. This mechanism makes it valuable for any condition with chronic neuroinflammation.